In a large bowl, combine chicken tenderloins, buttermilk, hot sauce, 1 tsp salt, and ½ tsp pepper. Cover and refrigerate for at least 15 minutes while you prepare the breading. For deeper flavor, marinate up to 4 hours.
In a shallow dish or pie plate, whisk together the flour, paprika, garlic powder, onion powder, cayenne, 1 tsp salt, and ½ tsp pepper until evenly combined.
Line a baking sheet with wire rack. Remove a tender from the buttermilk, letting excess drip off, then press firmly into the flour mixture on all sides. Shake off any loose flour and place on the rack. Repeat with all tenders. Let them sit for 5–10 minutes — this helps the coating adhere.
In a large heavy-bottomed pot or Dutch oven, pour oil to a depth of about 2 inches. Heat over medium-high until a deep-fry or instant-read thermometer registers 350°F (175°C). Carefully monitor the temperature.
Working in batches of 3–4, gently lower tenders into the hot oil. Fry for 3–4 minutes per side, until deep golden brown and the internal temperature reaches 165°F (74°C). Transfer to a paper towel-lined plate and immediately sprinkle with flaky sea salt.
Arrange the crispy chicken tenders on a platter with your choice of dipping sauces. Enjoy hot.